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US 6,673,538 B1Granted
Methods and compositions for designing vaccines
AssigneeTrustees of Boston University
InventorRichard N. Goldstein
Life of this patent
Estimating the term…
Abstract
Methods and compositions are described for determining a statistically significant number of different strains within a species of bacteria indicative of the species population structure as a whole in order to permit the evaluation of a vaccine target.
Claims14
A method for vaccine development, said method comprising carrying out, in the order given below, the steps of:
- a) providing a plurality of isolates of a single bacterial species, said isolates comprising DNA;
- b) examining said DNA from said isolates so as to produce a phylogenetic tree defining one or more phylogenetic subsets of said isolates, wherein said phylogenetic tree is produced prior to evaluation of a candidate vaccine target antigen and wherein construction of said tree is not based on examination of the DNA sequence of a gene encoding any candidate vaccine target antigen;
- and
- c) evaluating a candidate vaccine target antigen in a representative isolate from each of said one or more stubsets of isolates for variability.
1 more element
A method for vaccine development, said method comprising the steps of:
- a) providing one or more phylogenetic subsets of isolates, wherein said phylogenetic subsets of isolates are defined by a phylogenetic tree produced by a method comprising the steps of:
- 1) providing a plurality of isolates of a single bacterial species, said isolates comprising DNA;
- and
- 2) examining said DNA from said isolates so as to produce a phylogenetic tree defining one or more phylogenetic subsets of said isolates, wherein said phylogenetic tree is produced prior to evaluation of a candidate vaccine target antigen and wherein construction of said tree is not based on examination of the DNA sequence of a gene encoding any candidate vaccine target antigen;
- and
- b) evaluating a candidate vaccine target antigen in a representative isolate from each of said one or more subsets of isolates for variability.
3 more elements
Dependencies are inferred from the claim text.