Back to results
US 6,673,363 B2Granted
Transdermal and topical administration of local anesthetic agents using basic enhancers
AssigneeDermatrends, Inc.
InventorsEric C. Luo, Nicole T. Gricenko, Tsung-Min Hsu
Life of this patent
Estimating the term…
Abstract
Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of local anesthetic agents. The methods entail the use of a base in order to increase the flux of the agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.
Claims33
A method for enhancing the flux of a local anesthetic agent through a body surface, comprising:
- (a) administering the local anesthetic agent to a localized region of a human patient's body surface;
- and
- (b) administering a basic permeation enhancer to the localized region, the enhancer comprising a pharmaceutically acceptable inorganic base and being present in an amount effective to provide a pH within the range of about 8.0-13.0 at the localized region of the body surface during administration of the local anesthetic agent and to enhance the flux of the local anesthetic agent through the body surface without causing damage thereto.
Dependencies are inferred from the claim text.