Compounds and methods for the diagnosis and treatment of ehrlichia infection
AssigneeCorixa Corporation
InventorsSteven G. Reed, Michael J. Lodes, Raymond L. Houghton, Patricia D. McNeill
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Abstract
Compounds and methods for the diagnosis and treatment of Ehrlichia infection, inparticular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containingsuch polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
Claims3
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) sequences encoded by the polynucleotide of SEQ ID NO:
- 84;
- (b) sequences having at least 70% identity to a sequence encoded by SEQ ID NO:
- 84;
- and
- (c) sequences having at least 90% identity to a sequence encoded by SEQ ID NO:
- 84;
- wherein the polypeptide possesses an ability to react with antisera raised against a polypeptide of SEQ ID NO:
- 85.
Dependencies are inferred from the claim text.