Compositions and methods for treating papillomavirus-infected cells
AssigneePresident and Fellows of Harvard College
InventorsPeter M. Howley, John Benson, Hiroaki Kasukawa
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Abstract
By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
Claims17
A peptide comprising an amino acid sequence consisting essentially of 15 to 25 contiguous amino acids of SEQ ID NO:
- 19 or SEQ ID NO:
- 19 wherein H7, C12, Y16 and/or K17 is replaced with alanine, wherein the peptide inhibits the interaction between HPV E1 and E2 proteins, and wherein the peptide is not a wildtype full length HPV E2 protein.
Dependencies are inferred from the claim text.