Method of inactivating microorganisms
OwnerSimon Johannes Bartelinginventor
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Abstract
This invention provides methods of inactivating a microorganism and preparing a vaccine including the step of applying to said microorganism a cross-linking agent simultaneously with a separate inactivant. This invention further relates to vaccines prepared by such methods and a kit including such inactivated microorganism. The cross-linking agent is typically formaldehyde (FA) and the inactivant typically binary ethyleneimine (BEI).
Claims28
A method of inactivating a microorganism comprising applying to said microorganism a cross-linking agent simultaneously with an aziridine compound.
A method of manufacturing a vaccine comprising providing a pathogen, inactivating the pathogen by applying to said pathogen a cross-linking agent simultaneously with an aziridine compound, and producing a vaccine from the inactivated pathogen.
A method of manufacturing a vaccine comprising providing a viral pathogen, inactivating the pathogen by applying to said pathogen a cross-linking agent simultaneously with a separate inactivant, and producing a vaccine from the inactivated pathogen.
Dependencies are inferred from the claim text.