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US 6,673,346 B1Granted
Compositions and methods for the treatment of sepsis
AssigneeThe Regents of the University of Michigan
InventorsPeter A. Ward, Markus Huber-Lang, Vidya Sarma, Boris Czermak
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Abstract
The present invention relates to compositions and methods for the prevention and treatment of blood-borne and toxin mediated diseases, and in particular anti-C5a antibodies for the prevention and treatment of sepsis in humans as well as other animals. The present invention also relates to methods of generating anti-C5a antibodies employing C-terminal truncated C5a peptides.
Claims3
A method of producing polyclonal antibodies, comprising:
- a) providing;
- i) an animal, and
- ii) an immunogenic composition, wherein said composition comprises a C-terminal truncated C5a peptide selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:14, SEQ ID NO:15, and SEQ ID NO:16;
- and
- b) immunizing said animal with said immunogenic composition under conditions such that antibodies are generated.
2 more elements
Dependencies are inferred from the claim text.