US 6,673,344 B1Granted

Antibodies to human CKβ-10/MCP-4

AssigneeHuman Genome Sciences, Inc.

InventorsHaodong Li, Mark Adams, Solange Hanschke Lima, Ralph Alderson, Yuling Li, David Parmelee, John White, Edward Appelbaum

Life of this patent

Estimating the term…

patentgrep

Loading patent…

Abstract

Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Claims54

Dependent claims

An isolated antibody, or portion thereof, that specifically. binds to a protein selected from the group consisting of:

(a) a protein consisting of amino acid residues 28 to 93 of SEQ ID NO:4;
(b) a protein consisting of amino acid residues 28 to 95 of SEQ ID NO:4;
(c) a protein consisting of amino acid residues 28 to 98 of SEQ ID NO:4;
(d) a protein consisting of amino acid residues 24 to 98 of SEQ ID NO:4;
(e) a protein consisting of amino acid residues 22 to 98 of SEQ ID NO:4;
(f) a protein consisting of amino acid residues 20 to 98 of SEQ ID NO:4;
(g) a protein consisting of amino acid residues 17 to 98 of SEQ ID NO:4;
(h) a protein consisting of amino acid residues 2 to 98 of SEQ ID NO:4;
(i) a protein consisting of amino acid residues 1 to 98 of SEQ ID NO:4;
(k) the full-length protein encoded by the cDNA contained in ATCC Deposit No. 75849;
(k) the full-length protein, excluding the N-terminal methionine residue, encoded by the cDNA contained in ATCC Deposit No. 75849;
and
(I) the mature protein encoded by the cDNA contained in ATCC Deposit No. 75849.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/717,209Filed 22 Nov 2000 · division
Priority: 23 Aug 1994
Granted: 6 Jan 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07K 14/52
From animals; from humans: cytokines; Lymphokines; Interferons
C07K 14/523
Chemokines: beta-chemokines, e.g. rantes, i-309/tca-3, mip-1alpha, mip-1beta/act-2/ld78/scif, mcp-1/mcaf, mcp-2, mcp-3, ldcf-1, ldcf-2
Y10S 930/14
Peptide or protein sequence: lymphokine; related peptides
C07K
Peptides

Family

PCT/US94/09484Parent of this continuation-in-part · filed 23 Aug 1994
Application08/458,355Parent of this continuation-in-part · filed 2 Jun 1995
Application08/462,967Parent of this continuation-in-part · filed 5 Jun 1995
Application08/613,822Parent of this division · filed 23 Feb 1996
US 5,981,230 AParent of this continuation-in-part · filed 9 Nov 1999
US 6,174,995 B1Parent of this division · filed 16 Jan 2001
Application08/613,822Parent of this continuation-in-part
US 6,673,344 B1This patent

From the US filing history. Foreign family members aren’t listed.