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US 6,673,334 B1Granted
Light sensitive compounds for instant determination of organ function
AssigneeMallinkcrodt, Inc.
InventorsSamuel Achilefu, Hermo N. Jimenez, Raghavan Rajagopalan, Richard B. Dorshow, Joseph E. Bugaj
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Abstract
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
Claims9
A method for performing a diagnostic or therapeutic procedure comprising administering to a mammal an effective amount of the benzoindole of formula
- Formula 4
- wherein R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R35 and R36, Y4, and Z4 are;
- W4 and X4 are —CRcRd;
- V4 is a single bond a4 and b4 are 0 d is 1;
- c is 1;
- and Rc, and Rd are defined in the same manner as Y4.
3 more elements
Dependencies are inferred from the claim text.