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US 6,673,333 B1Granted
Functional MRI agents for cancer imaging
AssigneeResearch Corporation Technologies, Inc.
InventorsThomas J. Meade, Scott Fraser, Russell Jacobs
Life of this patent
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Abstract
The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.
Claims10
An MRI agent having the formula:
- wherein said linker is selected from the group consisting of aryl or alkyl groups;
- and,
- wherein said carbohydrate binds β-glucuronidase.
An MRI agent having the formula:
- wherein said linker is selected from the group consisting of aryl or alkyl groups;
- and,
- wherein upon interaction with β-glucuronidase, the T1 of the agent is decreased.
An MRI agent having the following formula:
- wherein said linker is selected from the group consisting of aryl or alkyl groups.
An MRI agent having the following formula:
- wherein said linker is selected from the group consisting of aryl or alkyl groups;
- and wherein upon interaction of the β-glucuronide moiety with β-glucuronidase, the T1 of the agent is decreased.
An MRI agent having the following formula:
A composition comprising an MRI agent according to 1, 2, 3, 4, or 7 and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.