Assays for inhibitors of neuronal transport of Alzheimer's amyloid precursor protein

A method for identifying modulators of transport of amyloid precursor protein comprising the steps of:

• a) providing:
• i) kinesin-I,
• ii) amyloid precursor protein, and
• iii) a test compound suspected of having modulating activity;
• b) combining said kinesin-1, said amyloid precursor protein, and said test compound under conditions such that said kinesin-I and said amyloid precursor protein will bind to produce a kinesin-I/amyloid precursor protein complex;
• and
• c) detecting modulation in the binding of said kinesin-I to said amyloid precursor protein in the presence of said test compound compared to in the absence of said test compound, thereby identifying said test compound as a modulator of transport of amyloid precursor protein.