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US 6,670,330 B1Granted
Cancer chemotherapy with 2-deoxy-D-glucose
OwnerTheodore J. Lampidis, Waldemare Priebeinventors
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Abstract
A class of glycolytic inhibitors is useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will significantly increase the efficacy of standard cancer chemotherapeutic and radiation regiments as well as new protocols emerging with anti-angiogenic agents.
Claims1
A method for treating human breast cancer which contains both aerobically and anaerobically metabolizing cells, said method comprising the steps of administering to a patient in need thereof:
- (a) at least one of docetaxel and paclitaxel for killing at least some of the aerobically metabolizing cells;
- and
- (b) 2-Deoxy-D-glucose for killing at least some of the anaerobically metabolizing cells.
Dependencies are inferred from the claim text.