Mutant Plk protein and gene encoding the same
AssigneeRiken
InventorsHiroyuki Osada, Siro Simizu
Life of this patent
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Abstract
A mutant Plk protein having a mutation in C-terminal domain thereof specified by amino acid residues of from 439 to 603 of amino acid sequence of wild-type Plk protein wherein said mutation decreases affinity with Hsp90 protein, and a gene encoding said mutant Plk protein are provided. A method for detecting an abnormal cell which comprises the step of detecting the mutant Plk protein or the gene encoding the protein is also provided.
Claims7
An isolated mutant Plk protein having at least one of S487G, P509S, N496S and R512W mutation in C-terminal domain of wild-type Plk protein, wherein said mutation decreases affinity with Hsp90 protein.
Dependencies are inferred from the claim text.