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US 6,670,168 B1Granted
Recombinant Streptomyces hygroscopicus host cells that produce 17-desmethylrapamycin
AssigneeKosan Bioscience
InventorsLeonard Katz, Lu Liu, Loleta M. Chung
Life of this patent
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Abstract
Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.
Claims1
A recombinant Streptomyces hygroscopicus host cell that produces 17-desmethylrapamycin,
- wherein the cell comprises a modified rapamycin polyketide synthase (PKS) gene cluster expressing a modified rapamycin PKS,
- and wherein said modified rapamycin PKS comprises an acyltransferase (AT) domain in extender module 10 having malonyl CoA specificity.
Dependencies are inferred from the claim text.