TWIK-5 potassium channel nucleic acids and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorRory A. J. Curtis
Life of this patent
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Abstract
The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK gene has been introduced or disrupted. The invention still further provides isolated TWIK proteins, fusion proteins, antigenic peptides and anti-TWIK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims63
An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleic acid sequence of SEQ ID NO:10, wherein the nucleic acid molecule encodes a polypeptide having [TWIK-5] potassium channel activity, or a full complement thereof.
An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleic acid sequence of SEQ ID NO:12, wherein the nucleic acid molecule encodes a polypeptide having [TWIK-5] potassium channel activity, or a full complement thereof.
An isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the DNA insert of the plasmid deposited with ATCC as Accession number PTA-1640, wherein the nucleic acid molecule encodes a polypeptide having [TWIK-5] potassium channel activity, or a full complement thereof.
An isolated nucleic acid molecule comprising the nucleic acid sequence of SEQ ID NO:10 or SEQ ID NO:12, or a full complement thereof.
An isolated nucleic acid molecule consisting of the nucleic acid sequence of SEQ ID NO:10 or SEQ ID NO:12, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:11, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO:11, or a full complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 95% identical to the amino acid sequence of SEQ ID NO:11, wherein the polypeptide has [TWIK-5] potassium channel activity.
An isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least 95% identical to the amino acid sequence encoded by the DNA insert of the plasmid deposited with ATCC as Accession Number PTA-1640, wherein the polypeptide has [TWIK-5] potassium channel activity.
Dependencies are inferred from the claim text.