Human EP3 prostaglandin receptor
AssigneesAllergan, Inc., Arizona Board of Regents
InventorsDaniel W. Gil, John W. Regan
Life of this patent
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Abstract
A gene encoding the human EP3 prostaglandin receptor has been cloned and sequenced. The protein encoded by this gene has seven transmembrane domains and is 81% homologous to the murine EP3 receptor. Two variants that differ in their carboxy terminal coding sequence, and one variant that differs in its 3′ untranslated sequence only, have also been cloned. The proteins, when expressed in eukaryotic cells, are capable of binding prostaglandins and their agonists and regulating adenylate cyclase activity in response to prostaglandins.
Claims7
A method of identifying modulators of a human prostaglandin EP3 receptor comprising the steps:
- i) contacting a test compound with an isolated or recombinant human EP3 receptor;
- and
- ii) directly or indirectly measuring the effect, if any, of said compound on an activity of said EP3 receptor as an indication of whether said compound is a modulator of said EP3 receptor protein.
Dependencies are inferred from the claim text.