Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents
AssigneeLudwig Institute for Cancer Research
InventorsXuri Li, Karin Aase, Ulf Eriksson
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Abstract
A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B186, determining an increased expression of VEGF-B186, or by determining an increased expression of VEGF-B186 relative to expression of VEGF-B167. The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B186 from the sample. Also, a method for screening for anti-tumor agents.
Claims21
A method for detecting the presence of tumor cells in an animal suspected of having a tumor, comprising the steps of:
- obtaining a sample from said animal;
- measuring in a VEGF-B186-specific manner, the expression level of VEGF-B186 in said sample;
- determining the control expression level of VEGF-B186 in an equivalent sample from an animal not suspected of having a tumor;
- and
- comparing said measured expression level with said control expression level,
- wherein determination of an increased expression of VEGF-B186 over the control expression is indicative of the presence of tumor cells.
A method for detecting the presence of tumor cells in an animal suspected of having a tumor, comprising the steps of:
- obtaining a sample from said animal;
- determining the expression level of VEGF-B186 in said sample;
- determining the expression level of VEGF-B167 in said sample;
- and
- comparing said expression level of VEGF-B186 with said expression level of VEGF-B167,
- wherein a comparison demonstrating a relative ratio of VEGF-B186 to VEGF-B167 greater than or equal to 28% is indicative of the presence of tumor cells.
A method for detecting the presence of tumor cells in an animal suspected of having a tumor, comprising the steps of:
- obtaining a sample from said animal;
- determining the expression level of VEGF-B186 in said sample;
- determining the expression level of VEGF-B167 in said sample;
- and
- comparing said expression level of VEGF-B186 with said expression level of VEGF-B167,
- wherein a comparison demonstrating a relative ratio of VEGF-B186 to VEGF-B167 greater than or equal to 50% is indicative of the presence of tumor cells.
Dependencies are inferred from the claim text.