Light stabilized antimicrobial materials
AssigneeBristol-Myers Squibb Company
InventorsDavid Parsons, Elizabeth Jacques, Philip Bowler
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Abstract
Methods of enhancing the photostabilizing of silver in medical materials are described. More particularly, the methods increase the photostabilization of silver in certain materials comprising hydrophilic, amphoteric and anionic polymers by subjecting the polymers to solutions containing an organic solvent and silver, during or after which one or more agents are added which facilitate the photostablization of the material.
Claims20
A method of preparing a light stabilized antimicrobial material comprising the steps of
- a) preparing a solution comprising an organic solvent and a source of silver in a quantity sufficient to provide a desired silver concentration in the light stabilized antimicrobial material;
- b) subjecting a polymer to the solution for a time sufficient to incorporate the desired silver concentration into the polymer, wherein the polymer is selected from the group consisting of a polysaccharide, a modified polysaccharide, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyvinyl ether, a polyurethane, a polyacrylate, a polyacrylamide, a collagen, a gelatin, and a mixture thereof;
- and
- c) subjecting the polymer, during or after step (b), to one or more agents which facilitate the binding of the silver on the polymer;
- wherein the silver is substantially photostable in the light stabilized antimicrobial material when dry, but will dissociate from the light stabilized antimicrobial material upon hydration of the light stabilized antimicrobial material.
A method of preparing a light stabilized antimicrobial material comprising the steps of
- a) preparing a solution comprising an organic solvent and a source of silver in a quantity sufficient to provide a desired silver concentration in the light stabilized antimicrobial material;
- b) subjecting a polymer to the solution for a time sufficient to incorporate the desired silver concentration into the polymer;
- and
- c) subjecting the polymer, after step (b), to one or more agents which facilitate the binding of the silver on the polymer;
- wherein the silver is substantially photostable in the light stabilized antimicrobial material when dry, but will dissociate from the light stabilized antimicrobial material upon hydration of the light stabilized antimicrobial material.
Dependencies are inferred from the claim text.