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AssigneeCLL Pharma
InventorsClaude Laruelle, Noël Zakarian, René Gimet, Dominique Toselli
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The invention relates to pharmaceutical dosage forms with rapid disintegration in the mouth and to their process of preparation. These pharmaceutical dosage forms comprise at least one active principle dispersed in a mixture of excipients and are characterized in that the mixture of excipients comprises at least one weakly compressible diluting agent other than trehalose and a copolymer of 1-vinylpyrrolidin-2-one and of vinyl acetate. Applications: oral administration of a great many active principles (analgesics, antispasmodics, agents used in gastroenterology, agents for combating motion sickness, antimigraines, β-blockers, antihistaminics, antibiotics or antibacterials, antivertigos, hypnotics, and the like).
Pharmaceutical dosage form uncoated tablet with the property of disintegration in the mouth in up to about 50 seconds comprising at least one active principal dispersed in a mixture of excipients, characterized in that the mixture of excipients comprises at least one weakly compressible diluting agent other than trehalos and a binding and disintegrating agent which is a copolymer of 1-vinyl pyrrolidin-2-one and of vinyl acetate, said weakly compressible diluting agent being present in a ratio by weight, with respect to said copolymer, of between 1.5 and 30 to 1.
Dependencies are inferred from the claim text.