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US 6,669,956 B2Granted
Tablets incorporating isoflavone plant extracts and methods of manufacturing them
AssigneesIndena S.p.A., Johnson & Johnson Consumer Companies, Inc.
InventorsMin Michael He, Fang-Yu Liu, Joseph A. Fix, Martin Link, Maria L. Kang, Ezio Bombardelli
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Abstract
The invention is directed to novel tablets comprising isoflavone-containing plant extract and water-insoluble polysaccharides, and methods of manufacturing them.
Claims20
A direct compression process for producing a tablet comprising the following steps:
- (a) mixing an initial formulation comprising
- an isoflavone-containing plant extract,
- a water-insoluble polysaccharide, wherein the amount of the water-insoluble polysaccharide in the tablet comprises at least about 15% of the dry weight of the tablet,
- a filler, and
- a silica gel glidant wherein the amount of the silica gel in the tablet comprises between about 1% to about 5% of the dry weight of the tablet;
- (b) milling the mixed formulation;
- (c) mixing into the milled and mixed formulation a micronized stearic acid, wherein the amount of the micronized stearic acid in the tablet comprises between about 1% to about 5% of the dry weight of the tablet;
- and
- (d) pressing the milled formulation into a tablet form, wherein the compression force of the press on the tablet is at least about 15 kilopounds.
6 more elements
The method wherein the plant water-insoluble polysaccharide is a soybean plant water-insoluble polysaccharide.
Dependencies are inferred from the claim text.