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AssigneeLongwood Pharmaceutical Research, Inc.
InventorsShubha Chungi, Theodore L. Iorio
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An orally administrable pharmaceutical formulation is provided that combines, as active agents, a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, aspirin, and optionally at least one of vitamin B6, B12, and folate; the active agents are each present in a unit dose appropriate for once-daily dosing, and at least one of the active agents is contained in a dosage unit within the dosage form that physically separates it from the other active agents. The formulation is provided as a simple and convenient therapy to reduce the risk of cardiovascular events in individuals who are at elevated cardiovascular risk, including individuals who have systemic lupus erythematosus. The formulation is also therapeutic for individuals during or immediately following an occurrence of acute myocardial infarction.
An orally administrable pharmaceutical dosage form for treating a patient at an elevated cardiovascular risk, comprising a combination of:
An orally administrable pharmaceutical dosage form for treating a patient at an elevated cardiovascular risk, comprising:
A packaged kit for a patient at an elevated cardiovascular risk to use in the self-administration of multiple oral dosage forms, the kit including a container housing a plurality of oral dosage forms and instructions for carrying out drug administration therewith, the improvement comprising incorporating in said oral dosage forms a combination of active agents comprised of:
Dependencies are inferred from the claim text.