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US 6,669,954 B2Granted
Controlled release of drugs
OwnerJohn R. Crison, Gordon L. Amidoninventors
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Abstract
A device for controlled release of pharmaceutical agents and a method for use of the device. The drug delivery device comprises a covered container with an aperture and an aperture cover, containing a pharmaceutical agent and an excipient formulation.
Claims43
A drug delivery system comprising:
- (a) a therapeutic amount of a pharmaceutical agent;
- (b) a container having (i) at least one aperture and (ii) a wall having an inside and an outside;
- (c) an excipient formulation disposed in said container regulating a diffusional boundary for said pharmaceutical agent, wherein the diffusional boundary layer is confined within said container for a period of time to allow drug delivery to a desired location and continuously releasing said pharmaceutical agent upon solvation at a rate of less than one-fifth of the initial release of said pharmaceutical agent in an uncoated form, the excipient formulation comprising a release control agent and an ingredient selected from the group consisting of:
- a lubricating agent, a filling agent and a mixture thereof, the ratio of the release control agent to the ingredient ranging from 0.2 to 170;
- and
- (d) a cover layer adhered to the wall, wherein at least one of the container or the cover layer is semi-permeable to said pharmaceutical agent.
3 more elements
A process for drug delivery comprising the step of administering to an individual a drug delivery device comprising:
- (a) a therapeutic amount of a pharmaceutical agent;
- (b) a container having (i) at least one aperture and (ii) a wall having an inside and an outside;
- (c) an excipient formulation disposed in said container regulating a diffusional boundary for said pharmaceutical agent, wherein the diffusional boundary layer is confined within said container for a period of time to allow drug delivery to a desired location and continuously releasing said pharmaceutical agent upon solvation at a rate of less than one-fifth of the initial release of said pharmaceutical agent in an uncoated form, the excipient formulation comprising a release control agent and an ingredient selected from the group consisting of:
- a lubricating agent, a filling agent and a mixture thereof, the ratio of the release control agent to the ingredient ranging from 0.2 to 170;
- and
- (d) a cover layer adhered to the wall, wherein at least one of the container or the cover layer is semi-permeable to said pharmaceutical agent.
3 more elements
Dependencies are inferred from the claim text.