Defective adenoviruses including a therapeutic gene and an immunoprotectove gene
AssigneeAventis Pharma S.A.
InventorsMichel Perricaudet, Martin Lee
Life of this patent
Estimating the term…
Abstract
Novel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a first recombinant DNA containing a therapeutic gene and a second recombinant DNA containing an immunoprotective gene, are disclosed.
Claims28
A replication defective adenoviral vector comprising a first and second recombinant DNA sequence inserted into an adenoviral genome having a deleted or non-functional E3 region, wherein the first recombinant DNA sequence can be expressed from the vector and wherein the second recombinant DNA sequence comprises the adenoviral immunoprotective E3 gp19k coding region linked to a non-adenoviral promoter, and wherein the adenoviral vector is capable of prolonged expression of the first and second recombinant DNA sequences compared to a control adenovirus.
A replication defective adenoviral vector comprising a first and second recombinant DNA sequence inserted into an adenoviral genome having a deleted or non-functional E3 region, wherein the first recombinant DNA sequence can be expressed from the vector and wherein the second recombinant DNA sequence comprises the herpes simplex virus ICP47 coding region linked to a non-adenoviral promoter, and wherein the adenoviral vector is capable of prolonged expression of the first and second recombinant DNA sequences compared to a control adenovirus.
Dependencies are inferred from the claim text.