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US 6,669,926 B1Granted
Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
AssigneeMallinckrodt Inc.
InventorsSamuel Achilefu, Raghavan Rajagopalan, Richard B. Dorshow, Joseph E. Bugaj
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Abstract
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
Claims9
A method for performing a diagnostic or therapeutic procedure comprising administering to a mammal an effective amount of the benzoindole of formula
- wherein R8, R9, R10, R11, R12, R13 to R14, and Y2 are H and W2 is S.
Dependencies are inferred from the claim text.