Method and device for producing different solid dosage forms
AssigneeAbbott Laboratories
InventorsJörg Rosenberg, Werner Maier
Life of this patent
Estimating the term…
Abstract
The invention relates to a process and an apparatus for producing solid dosage forms by molding plastic active ingredient-containing mixtures with use of a continuously operating molding tool with two parts which cooperate to mold the plastic mixture, with at least one part having a plurality of depressions to receive and mold the plastic mixture, wherein one part has at least two groups, which differ in volume and/or shape, of depressions. Dosage forms which differ in shape or size are obtained in one step.
Claims7
A process for producing solid dosage forms, comprising
- i) mixing a thermoplastic, physiologically tolerated polymeric binder which is convertible into a platic state in the range of from 50 to 160° C., at least one active ingredient and, optionally, conventional additives,
- ii) converting the mixture into a plastic mixture, and
- iii)feeding the plastic mixture into a molding tool with two parts which cooperate to mold the plastic mixture, with at least one part having a plurality of depressions to receive and mold the plastic mixture, wherein one part has at least two groups, which differ in volume and/or shape, of depressions.
An apparatus for producing various dosage forms comprising two molding rolls which cooperate to mold a plastic mixture,
- a) the molding rolls having a plurality of depressions to receive and mold the plastic mixture,
- b) the molding rolls rotating in opposite directions and the outlines of the depressions in one molding roll essentially coinciding pairwise with the outlines of the depressions in the other molding roll in the gap between the molding rolls, and
- c) at least one molding roll having at least two groups of depressions which differ in volume and/or shape, wherein the depressions are shaped and arranged on the surfaces of the rolls so that both a first and a second orientation of the molding rolls is possible, it being possible to convert the first orientation into the second orientation by rotating one of the two molding rolls by 180° relative to at least one axis perpendicular to the long axis of this molding roll, and vice versa.
Dependencies are inferred from the claim text.