Method for producing solid dosing forms
AssigneeAbbott Laboratories
InventorsReinhard Spengler, Jörg Rosenberg
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Abstract
A process for producing solid dosage forms by forming a plastic mixture of at least one polymeric binder, at least one active ingredient and, where appropriate, conventional additives, and shaping the plastic mixture to the solid dosage forms using a mold, wherein an agent which modifies the surface properties is applied in finely divided form to the surface of the plastic, mixture during the shaping is described. The agent which modifies the surface properties is preferably a surfactant, a lipophilic compound, an antioxidant, a coloring agent or an agent with antistatic effect and/or lubricant effect.
Claims9
A process for producing solid dosage forms by forming a plastic mixture of 10 to 99.9% by weight of at least one polymeric binder, 0.1 to 90% by weight of at least one active ingredient and, where appropriate, conventional additives, and shaping the solvent-free plastic mixture to the solid dosage forms using a mold, wherein an agent which modifies the surface properties is applied in finely divided form to the surface of the plastic mixture during the shaping, wherein the agent which modifies the surface properties is initially applied in finely divided form to the surfaces of the mold which come into contact with the plastic mixture to be shaped, and every contact of the surfaces of the mold with the plastic mixture is followed by a new application of the agent which modifies the surface properties.
Dependencies are inferred from the claim text.