Macrocyclic antibiotics as separation agents
AssigneeThe Curators of the University of Missouri
InventorDaniel Armstrong
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Abstract
Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof. The process has been found to be especially advantageous for separation of optical isomers by electrophoresis and chromatography.
Claims10
A separation material for sequentially separating enantiomers from a fluid solution containing said enantiomers wherein a fluid containing said enantiomers comes in contact with said material to cause said enantiomers to sequentially separate one from another, said material being a macrocyclic antibiotic chemically bonded by a spacer to a support and said macrocyclic antibiotic is selected from the group consisting of ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof, said macrocyclic antibiotic interacting with said enantiomers to cause sequential separation by means of more than one of the following mechanisms:
- complexation, charge-charge interaction, hydrogen bonding, inclusion in a hydrophobic pocket, dipole stacking, or steric interaction.
Dependencies are inferred from the claim text.