Medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases
AssigneeMagForce Applications GmbH
InventorAndreas Jordan
Life of this patent
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Abstract
A medical preparation for treating arthrosis, arthritis and other rheumatic joint diseases comprises a suspension consisting of one-shelled or multi-shelled nanoscalar particles composed of a core containing iron oxide and of an inner shell with groups capable of forming cationic groups or, optionally, of at least one outer shell with neutral and/or anionic groups. Radionuclides and substances, said substances being cytotoxically active when subjected to heat, are bound to the inner shell. The preparation that is injected into the joint cavity and subjected to an alternating electromagnetic field promises an excellent treatment outcome due to the high rate of phagocytosis and the trimodal combinatorial effect of thermotherapy, radiotherapy and chemotherapy.
Claims9
A medical preparation including nanoscalar particles that generate heat when an alternating electromagnetic field is applied, said nanoscalar particles comprising:
- a core containing iron oxide and an inner shell with groups that are capable of forming cationic groups, wherein the iron oxide concentration is in the range from 0.01 to 50 mg/ml of synovial fluid at a power absorption in the range from 50 to 500 mW/mg of iron and heating to a temperature in the range from 42 to 50° C.;
- and
- pharmacologically active species bound to said inner shell selected from the group consisting of thermosensitizers and thermosensitive chemotherapeutics or isotopes thereof;
- wherein said preparation is used for treating arthrosis, arthritis and rheumatic joint diseases by directly injecting said nanoscalar particles into the synovial fluid, said nanoscalar particles being absorbed by said fluid and transported to the inflamed synovial membrane where they are activated after a predefined period of time by applying said alternating electromagnetic field.
A medical preparation including nanoscalar particles that generate heat when an alternating electromagnetic field is applied, said nanoscalar particles comprising:
- a core containing iron oxide and an inner shell with groups that are capable of forming cationic groups;
- and
- pharmacologically active radionuclides bound to said inner shell using chelating agents;
- wherein said preparation is adapted to be used for treating arthrosis, arthritis and rheumatic joint diseases by directly injecting said nanoscalar particles into the synovial fluid, said nanoscalar particles when injected being absorbed by said fluid and transported to the inflamed synovial membrane where they are activated after a predefined period of time by applying said alternating electromagnetic field.
Dependencies are inferred from the claim text.