System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment
AssigneeMedtronic, Inc.
InventorsKenneth B. Stokes, Josée Morissette
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Abstract
The present invention provides delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.
Claims8
An implantable system for pacing a patient's heart and for delivering a predetermined genetic material to cells adjacent to a pacing electrode positioned in said patient's heart, comprising:
- a supply of genetic material comprising cells containing DNA or RNA encoding an ion channel protein;
- a catheter, said catheter having proximal and distal ends, a lumen through at least a part thereof and connecting to said distal end, a pacing electrode positioned at said distal end for engaging said patient's heart wall, said electrode having a channel therethrough in communication with said lumen, and a conductor connecting said proximal end to said electrode,
- a pulse generator connected electrically to said conductor at said catheter proximal end for delivering pace pulses to said electrode,
- reservoir means for holding said supply of genetic material, and
- delivery means for delivering said genetic material from said reservoir to said lumen, whereby said material passes through said lumen and said channel to said heart wall.
Dependencies are inferred from the claim text.