Electrochemical saccharide sensor
AssigneeBeckman Coulter, Inc.
InventorsTony D. James, Susumu Arimori
Life of this patent
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Abstract
The invention provides compounds for detecting sacchharides by electrochemistry. The compounds have a structure that includes a first boronic acid group attached by a first linker group to a first tertiary amine. The first tertiary amine is attached to a reporter group that includes an organometalic reporter moiety. A spacer group attaches the first tertiary amine to a second tertiary amine. The second tertiary amine is attached to an R group and a second linker group. The second linker group is attached to a second boronic acid group. In preferred embodiments, the compound selectively detects glucose and has a higher relative stability constant for glucose than for other saccharides.
Claims20
A compound comprising a first boronic acid group attached by a first linker group to a first tertiary amine, the first tertiary amine attached to a reporter group comprising an organometalic reporter moiety, the first tertiary amine further attached by a spacer group to a second tertiary amine, the second tertiary amine attached to an R group and a second linker group, and the second linker group attached to a second boronic acid group.
A compound having the formula:
- wherein A is an aromatic ring or heteroaromatic ring, R1 comprises an organometalic reporter group, R2 is a linker group comprising an akyl or an aryl, R3 comprises hydrogen, an akyl, an aryl, or a organometalic reporter group, and B is an aromatic ring or heteroaromatic ring.
A compound for detecting glucose having the formula:
- where A is an aromatic ring or heteroaromatic ring, R1 is selected from the group consisting of hydrogen, akyl groups, aryl groups, and a organometalic reporter group, and B is an aromatic ring or heteroaromatic ring.
A compound for detecting glucose having the following formula:
Dependencies are inferred from the claim text.