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US 6,664,406 B1Granted
Nervonic acid derivatives, their preparation and use
AssigneeCroda International PLC
InventorsKeith Coupland, Yann Raoul
Life of this patent
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Abstract
The present invention relates to a nervonic acid derivatives of formula (I) CH3—(CH2)7—CH═CH—(CH2)13—C(O)—O—(CH2)3—OR (I) wherein R is hydrogen (H) or a residue of a carboxylic acid; or a salt of the compound where R is H; or a bioprecursor, prodrug thereof. Those compounds wherein R is other than H have pharmacological activity, in particular anti-inflammatory and immunomodulatory effects. Those compounds wherein R is H can be used to prepare the pharmacologically active derivatives.
Claims29
A compound of formula (I):
- CH3—(CH2)7—CH═CH—(CH2)13—C(O)—O—(CH2)3—OR (I)
- wherein R is a compound selected from the group consisting of hydrogen (H) and a residue of a carboxylic acid;
- and salts of the compound where R is H;
- and bioprecursors, prodrugs and hydrates thereof.
1 more element
A compound selected from the group consisting of:
- 1-(z-15-tetracosenoyloxy)-3-hydroxypropane;
- 1-(z-15-tetracosenoyloxy)-3-(z,z,z-6,9,12-octadecatrienoyloxy)propane (hereinafter referred to as NA:GLA);
- 1-(z-15-tetracosenoyloxy)-3-(z,-4,7,10,13,16,19-docosahexaenoyloxy)propane (hereinafter referred to as NA:DHA);
- and
- 1,3-di-(z-15-tetracosenoyloxy)propane (hereinafter referred to as NA:NA).
2 more elements
Dependencies are inferred from the claim text.