Derivatives of butyric acid
AssigneeBoard of Trustees of the University of Arkansas
InventorsKathleen Gilbert, E. Kim Fifer
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Abstract
The present invention provides a series of compounds having structural formulas wherein n1 is 1 to 5, n2 is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein R′ is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n1 is not 1; and wherein X and R′ are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in an individual.
Claims4
The compound of the structure
- wherein n1 is 1 to 5;
- n2 is 1 to 4;
- R′ is selected from the group consisting of hydrogen, methyl and ethyl;
- and
- X is O;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.