Kidney injury-related molecules
AssigneeBiogen, Inc.
InventorsMichele Sanicola-Nadel, Joseph V. Bonventre, Catherine Hession, Takaharu Ichimura, Henry Wei, Richard L. Cate
Life of this patent
Estimating the term…
Abstract
Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.
Claims19
An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide comprising amino acids 1-290 of SEQ ID NO:7.
An isolated DNA comprising nucleotides 278-1147 of SEQ ID NO:6 or the DNA complement of nucleotides 278-1147 of SEQ ID NO:6.
An isolated DNA comprising a nucleotide sequence encoding a polypeptide comprising amino acids 21-290 of SEQ ID NO:7.
A nucleic acid comprising a nucleotide sequence encoding a polypeptide comprising a mammalian KIM1 polypeptide lacking a KIM1 signal sequence, the mammalian KIM1 polypeptide being selected from the group consisting of SEQ ID NO:3 and SEQ ID NO:7.
A nucleic acid comprising a nucleotide sequence encoding a fusion protein comprising amino acids 21-290 of SEQ ID NO:7 and an Fc region of an immunolobulin.
Dependencies are inferred from the claim text.