US 6,664,376 B2 · Secreted and transmembrane polypeptides and nucleic acids encoding the same

Secreted and transmembrane polypeptides and nucleic acids encoding the same

AssigneeGenentech, Inc.

InventorsAvi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood

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Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims11

Dependent claims

An isolated polypeptide having at least 80% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide shown in FIG. 38 (SEQ ID No:
104);
(b) the amino acid sequence of the polypeptide shown in FIG. 38 (SEQ ID NO:
104), lacking its associated signal peptide;
or
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209400,
wherein said polypeptide has procallagen C-proteinase enhancing properties.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

09/905,125Filed 12 Jul 2001 · continuation

Priority

24 Oct 1997

Published

US 2003/0113719 A119 Jun 2003

Granted

16 Dec 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

C07K 14/47
From vertebrates: from mammals
C07H 21/00
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate
C07H 21/04
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
C07K 1/00
General methods for the preparation of peptides , i.e. processes for the

Family

Application60/063,128Us provisional application · filed 24 Oct 1997

PCT/US98/19330Parent of this continuation-in-part · filed 16 Sep 1998

PCT/US99/28313Parent of this continuation-in-part · filed 30 Nov 1999

PCT/US00/04414Parent of this continuation · filed 22 Feb 2000

Application09/665,350Parent of this continuation · filed 18 Sep 2000

US 2003/0113719 A1Pre-grant publication · published 19 Jun 2003

PCT/US00/04414Parent of this continuation-in-part

US 6,664,376 B2This patent

From the US filing history. Foreign family members aren’t listed.