Azatide peptidomimetics

A process for producing a combinatorial oligoazatide library comprising the following steps:

• Step A:
• providing a soluble homopolymer support with a linker unit attached to said soluble homopolymer support in each of “n” reaction vessels;
• then
• Step B:
• providing “n” Boc-protected aza-amino acids;
• then
• Step C:
• reacting each of the “n” Boc-protected aza-amino acid of said Step B with a carbonyl activation element for producing an activated carbamate of the Boc-protected aza-amino acids capable of coupling with the soluble homopolymer support or with a nascent protected chain thereon, the carbonyl activation element being bis-pentafluorophenyl carbonate;
• then
• Step D:
• adding one of the “n” activated carbamates of said Step C to each of the “n” reaction vessels and coupling the soluble homopolymer support of said Step A with the activated carbamate of said Step C for producing the nascent protected chain in each of the “n” reaction vessels;
• and then
• Step E:
• washing each of the nascent protected chain by precipitation of the soluble homopolymer;
• then
• Step F:
• saving and cataloging an aliquot from each of the “n” reaction vessels;
• then
• Step G:
• pooling all “n” of the reaction vessels into a common pot for forming a mixture of nascent protected chains;
• then
• Step H:
• deprotecting the nascent protected chain in each of the “n” reaction vessels using a mild acid for producing nascent deprotected chains;
• then
• Step I:
• washing each of the nascent deprotected chains by precipitation of the soluble homopolymer;
• Step J:
• equally aliquoting the mixture of nascent deprotected chains from the common pot into the “n” reaction vessels;
• then
• Step K:
• extending the nascent deprotected chains of said Step J by repeating steps A through I “m” times wherein 1≦m ≦100 and wherein the soluble homopolymer support of said Steps A and D is replaced with the nascent deprotected chain of said Step I for producing extended deprotected chains;
• and then
• Step L:
• decoupling and separating the extended deprotected chains in each of the “n” reaction vessels of said Step J from the soluble support by hydrogenation and precipitation, thus producing the combinatorial oligoazatide library.