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US 6,664,369 B1Granted
GnRH analogues with antitumour effects and pharmaceutical compositions thereof
AssigneeCreighton University
InventorsSandor Lovas, Richard F. Murphy, Geza Toth, Adrienn Kalnay, Istvan Palyi, Gizella Turi, Borbala Vincze, Imre Mezom, Zsolt Vadasz, Istvan Teplan, Janos Seprodi, Melinda Mora
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Abstract
The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumor effect. The invention additionally provides compositions including these peptides and compounds.
Claims2
A compound selected from the group consisting of:
- [Lys(ε-Fmoc)]5-gonadotropin-releasing hormone (GnRH-III,
- Lys5-GnRH-III,
- Lys5,cyclo[Asp6-Lys8]-GnRH-III,
- Lys5,[Lys(ε-Fmoc)]8-GnRH-III,
- Lys4,[Lys(ε-Fmoc)]8-GnRH-III,
- Lys4-GnRH-III,
- [Lys(ε-Ac)]4-GnRH-III,
- Glu6-GnRH-III,
- cyclo[ASP6-Lys8]-GnRH-III,
- D-Ala10-GnRH)-III,
- H-D-Trp1,[Lys(ε-Fmoc)]8, D-Ala10-GnRH-III,
- Ac-D-Trp1, D-Ala10-GnRH-III,
- H-D-Trp1, D-Ala10-GnRH-III,
- [Trp(For-Ind)]3,7-GnRH-III,
- Phe7-GnRH-III,
- GnRH-III(1-9)-ethylamide,
- Lys5, D-Trp6-human gonadotropin-releasing hormone (hGnRH),
- Lys4, D-Trp6-hGnRH,
- H-Glu1, D-Trp6-hGnRH,
- Lys5, D-Phe6-hGnRH(1-9)-ethylamide,
- Lys4, D-Phe6-hGnRH(1-9)-ethylamide,
- Lys5, D-Cpa6-hGnRH(1-9)-ethylanuide;
- as well as pharmaceutically acceptable salts and esters of these compounds.
20 more elements
Dependencies are inferred from the claim text.