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US 6,664,331 B2Granted
Poly(ethylene glycol) derivatives with proximal reactive groups
AssigneeNektar Therapeutics AL, Corporation
InventorsJ. Milton Harris, Antoni Kozlowski
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Abstract
An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.
Claims53
A conjugate comprising:
- a biologically active agent;
- and
- an activated, water soluble polymer comprising a polymer backbone having at least one terminus bonded to a branching atom through a hydrolytically stable linkage, the branching atom being covalently bonded to at least two reactive groups, each reactive group comprising a reactive moiety,
- said biologically active agent being covalently linked to at least one of said reactive groups, wherein the water soluble polymer does not hydrolyze.
1 more element
Dependencies are inferred from the claim text.