Use of cell membrane penetrating indigoid bisindole derivatives

A method for the treatment of human solid tumors and metastasis thereof comprising,

• administering a cell membrane penetrating indigoid bisindole derivative to a human in need thereof,
• wherein said human solid tumors and metastasis thereof are selected from carcinomas, melanomas, adenomas, sarcomas, lymphomas, neuroblastomas, teratomas, astrocytomas, glioblastomas, or mesotheliomas, and
• the indigoid bisindole derivative is selected from bis(3-phenylindol-2-yl), isoindigo or indirubin derivatives, the indirubin derivatives being represented by the following formula (I):
• wherein, X represents an oxygen atom or NOH, and
• when X represents an oxygen atom, R1 represents a hydrogen atom, a halogen atom, a —NO2 group, a methyl group, a sulfonamide group or SO2—NH—CH2CH2—OH;
• and
• when X represents NOH, R1 represents a hydrogen atom or an iodide atom.