Antivesicant compounds and methods of making and using thereof
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsAi J. Lin, Michael C. Babin
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Abstract
As disclosed herein, the present invention provides a compound having the structural formula wherein R1, R2, R3, and R4 are each independently H, or a methyl, halo, trifluoromethyl, nitro, alkyloxy, or acyloxy group, or a pharmaceutically acceptable salt or prodrug thereof. Also disclosed are compounds, compositions, methods and kits for treating, preventing, or inhibiting injuries induced by a vesicant agent, such as bis-2-chloroethylsulfide (HD). Additionally, protectants and decontaminants are disclosed.
Claims9
A method of treating, preventing, or inhibiting an injury induced by a vesicant agent comprising administering at least one compound selected from the group consisting of 2-mercaptopyridine-N-oxide and pharmaceutically acceptable salts thereof, 4-methyl-2-mercaptopyridine-N-oxide and pharmaceutically acceptable salts thereof, and 6-methyl-2-mercaptopyridine-N-oxide and pharmaceutically acceptable salts thereof to a subject in need thereof.
Dependencies are inferred from the claim text.