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US 6,664,272 B2Granted
Curcumin analogs with anti-tumor and anti-angiogenic properties
AssigneeEmory University
InventorsJames P. Snyder, Matthew C. Davis, Brian Adams, Mamoru Shoji, Dennis C. Liotta, Eva M. Ferstl, Ustun B. Sunay
Life of this patent
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Abstract
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
Claims37
A compound of the formula:
- wherein:
- R1-R8 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, CF3, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkaryl, arylalkyl, heteroaryl, substituted heteroaryl, heterocycle, Substituted heterocycle, amino, alkylamino, dialkylamino, carboxylic acid, carboxylic ester, carboxamide, nitro, cyano, azide, alkylcarbonyl, acyl, and trialkylammonium;
- X is O, S, SO, SO2, or NR, wherein R is selected from the group consisting of hydrogen, alkyl, alkoxy, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, substituted heterocycle, acyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl and dialkylaminocarbonyl;
- the dashed lines indicate the presence of optional double bonds;
- or
- pharmaceutically acceptable salt thereof.
3 more elements
A method of treating cancerous tissue in a subject, comprising administering to the subject an effective amount of a compound of formula
- wherein:
- each Y is independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, alkyl, amino, alkylamino, and dialkylamino;
- R1-R8 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, alkyl, amino, alkylamino, and dialkylamino;
- X is O, S, or NR;
- R is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, and substituted heterocycle;
- the dashed hues indicate the presence of optional double bonds;
- or pharmaceutically acceptable salt thereof.
4 more elements
A pharmaceutically formulation, comprising a compound of the formula:
- wherein:
- each Y is independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, alkyl, amino, alkylamino, and dialkylamino;
- R1-R8 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, alkyl, amino, alkylamino, and dialkylamino;
- X is O, S, or NR;
- R is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle, and substituted heterocycle;
- and
- the dashed lines indicate the presence of optional double bonds;
- or a pharmaceutically acceptable salt thereof;
- and
- a pharmaceutically acceptable carrier.
7 more elements
Dependencies are inferred from the claim text.