Method and composition for treatment of irritable bowel disease
AssigneeUniversity of Florida
InventorRaymond J. Bergeron, Jr.
Life of this patent
Estimating the term…
Abstract
A method and composition for treating irritable bowel syndrome in a subject in need of such treatment, utilizing an amount of a polyamine having the formula: RNH—(CH2)aNH(CH2)bNH(CH2)cNH2, 1) CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3, 2) R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 3) PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, 4) wherein: R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, PIP is piperidine and a, b, c, d, and e may be the same or different and are integers from 1-10 effective to treat irritable bowel syndrome.
Claims11
A method for treating irritable bowel syndrome in a subject in need of such treatment, comprising administering to said subject amounts of at least two polyamines effective to treat irritable bowel syndrome in said subject, said polyamines being selected from the group consisting of polyamines having the formula:
- R—NH—(CH2)a—NH—(CH2)bNH—(CH2)c—NH2, 1)
- CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3, 2)
- R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 3)
- PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, 4)
- wherein:
- R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of said alkyl chains may optionally be interrupted by at least one etheric oxygen atom,
- PIP is piperidine and
- a, b, c, d, and e may be the same or different and are integers from 1-10.
A pharmaceutical composition in unit dosage form adapted for administration to a subject suffering from irritable bowel syndrome comprising amounts of at least two polyamines therapeutically effective to treat irritable bowel syndrome and a pharmaceutically acceptable carrier therefore, said polyamine being selected from the group consisting of polyamines having the formula:
- R—NH—(CH2)a—NH—(CH2)bNH—(CH2)c—NH2, 1)
- CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H—CF3, 2)
- R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 3)
- PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, 4)
- wherein:
- R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to 10 about carbon atoms, and any of said alkyl chains may optionally be interrupted by at least one etheric oxygen atom,
- PIP is piperidine and
- a, b, c, d, and e may be the same or different and are integers from 1-10.
An article of manufacture comprising packaging material and at least two pharmaceutical agents contained within said packaging material, wherein said pharmaceutical agents are effective for the treatment of a subject suffering from irritable bowel syndrome, and wherein said packaging material comprises a label which indicates that said pharmaceutical agents can be used for ameliorating the symptoms associated with irritable bowel syndrome, and wherein said pharmaceutical agents are selected from the group consisting of polyamines having the formula:
- R—NH—(CH2)a—NH—(CH2)bNH—(CH2)c—NH2, 1)
- CF3—C6H5—(CH2)a—NH—(CH2)b—NH—(CH2)c—NH—(CH2)d—NH—(CH2)e—C6H5—CF3, 2)
- R—NH—(CH2)a—NH—C6H6—NH—(CH2)b—NH—R and 3)
- PIP—(CH2)aNH—(CH2)b—NH—(CH2)c—PIP, 4)
- wherein:
- R is alkyl, aryl, aralkyl, alkaryl, or cyclo-alkyl having up to about 10 carbon atoms, and any of said alkyl chains may optionally be interrupted by at least one etheric oxygen atom,
- PIP is piperidine and
- a, b, c, d, and e may be the same or different and are integers from 1-10.
Dependencies are inferred from the claim text.