Axon regeneration with PKC inhibitiors
AssigneeChildren's Medical Center Corporation
InventorsZhigang He, Vuk Koprivica, Rajeev Sivasankaran
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Abstract
Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
Claims9
A method for promoting regenerative growth of an adult human central nervous system spinal neuron axon in situ and damaged by a spinal injury and subject to growth inhibition by endogenous, myelin growth repulsion factors, the method comprising the steps of delivering to the axon a therapeutically effective amount of a specific inhibitor of a protein kinase C by locally administering to a human patient in need thereof at the axon said therapeutically effective amount of the inhibitor, whereby regenerative growth of the axon is promoted;
- and detecting a resultant promotion of the regenerative growth of the axon, wherein the inhibitor is selected from the group consisting of Ro-31-7549, Ro-31-8220, Ro-31-8425 and Ro-32-0432.
A method for promoting regenerative growth of an adult human central nervous system spinal neuron axon in situ and damaged by a spinal injury and subject to growth inhibition by endogenous, myelin growth repulsion factors, the method comprising the steps of delivering to the axon a therapeutically effective amount of a specific inhibitor of a Ca-dependent protein kinase C by locally administering to a human patient in need thereof at the axon said therapeutically effective amount of the inhibitor, whereby regenerative growth of the axon is promoted;
- and detecting a resultant promotion of the regenerative growth of the axon, wherein the inhibitor is selected from the group consisting of:
- Go6976, Go6983 and Go7874.
Dependencies are inferred from the claim text.