Back to results
US 6,664,263 B2Granted
1,8-naphthalimide imidazo{4,5,1-de}acridones with anti-tumor activity
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsWieslaw M. Cholody, Teresa Kosakowska-Cholody, Christopher J. Michejda
Life of this patent
Estimating the term…
Abstract
The invention provides imidazoacridone compounds of general formula (1) which have cytotoxic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirably high levels of cell proliferation. The compounds of the invention are also expected to have utility as research tools.
Claims20
A compound of structure 1:
- wherein
- A is (CH2)m or (CHR)m;
- B is NR′, NR′(CH2)nNR″, hexahydropyrimidine-1,3-diyl, piperazine-1,4diyl, 4-aminopiperidine-1,4N-diyl, or 1,4-diazacycloheptane-1,4-diyl;
- D is (CH2)p or (CHR)p;
- Y1, Y2, Y3 and Y4 are independently R, COR, CO2R, CONRR′, SR, SOR, SO2R, SO2CF3, SO2NRR′, OR, OCF3, OCOR, OCONRR′, NO2, NRR′, CN, Ph, CF3, NRCOR′, NRCONR′R″, NRC(NR′)NR″R′″, NRCOCF3, NRSO2R′, NRSO2CF3, or halogen;
- R is H, CF3, lower alkyl, amino-lower alkyl, or hydroxy-lower alkyl;
- R′ and R″ are independently R, C(O)R, or SO2R;
- and
- m, n, and p are independently 2-6.
6 more elements
Dependencies are inferred from the claim text.