4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof

A compound having the structure:

• wherein NR1R2 is substituted or unsubstituted (D)-2-aminocarbonyl pyrrolidino, (D)-2-hydroxymethyl pyrrolidino, (D)-2-hydroxymethyl-trans-4-hydroxy pyrrolidino, or piperazino;
• wherein R3 is a substituted or unsubstituted phenyl, pyrrole, thiophene, furan, thiazole, imidazole, pyrazole, 1,2,4-triazole, pyridine, 2(1K)-pyridone, 4 (1H)-pyridone, pyrazine, pyrimidine, pyridazine, isothiazole, isoxazole, oxazole, tetrazole, naphthalene, tetralin, naphthyridine, benzofuran, benzothiophene, indole, 2,3-dihydroindole, 1H-indole, indoline, benzopyrazole, 1,3-benzodioxole, benzoxazole, purine, coumarin, chromone, quinoline, tetrahydroquinoline, isoquinoline, benzimidazole, quinazoline, pyrido [2,3-b] pyrazine, pyrido [3,4-b] pyrazine, pyrido [3,2-c] pyridazine, purido [3,4-b]-pyridine, 1H-pyrazole [3,4-d ] pyrimidine, pteridine, 2(1K)-quinolone, 1(2H)-isoquinolone, 1,4-benzisoxazine, benzothiazole, quinoxaline, quinoline-N-oxide, isoquinoline-N-oxide, quinoxaline-N-oxide, quinazoline-N-oxide, benzoxazine, phthalazine, or cinnoline;
• wherein R5 is H, alkyl, substituted aikyl, aryl, arylalkyl, amino, substituted aryl, wherein said substituted alkyl is —C(R7) (R8)XR9, wherein X is O, S, or NR10, wherein R7 and R8 are each independently H or alkyl, wherein R9 and R10 are each independently alkyl or cycloalkyl, or R9, R10 and the nitrogen together form a substituted or unsubstituted ring of between 4 and 7 members;
• and
• wherein R6 is H, alkyl, substituted alkyl, or cycloalkyl.