Bicyclic vasopressin agonists
AssigneeFerring B.V.
InventorsDoreen Mary Ashworth, Gary Robert William Pitt, Peter Hudson, Christopher Martyn Yea, Richard Jeremy Franklin
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Abstract
Compounds according to general formula (1), and pharmaceutically acceptable salts thereof, wherein V is a covalent bond or NH, X is selected from CH2, O and N-alkyl, Z is either S or —CH═CH—, R1 and R2 are independently selected from H, F, Cl, Br and alkyl, R3 is selected from OH, O-alkyl and NR4R5, R4 and R5 are each independently H or alkyl, or together are —(CH2)q—, p is 0, 1, 2, 3 or 4, and q is 4 or 5, are new. They are agonists at the asopressin V2 receptor and are useful as antidiuretics and pro-coagulants.
Claims17
A compound of general formula 1 or a pharmaceutically acceptable salt thereof:
- wherein:
- V is a covalent bond or NH,
- X is selected from CH2, O and N-alkyl,
- Z is either S or —CH═CH—,
- R1 and R2 are independently selected from H, F, Cl, Br and alkyl,
- R3 is selected from OH, O-alkyl and NR4R5,
- R4 and R5 are each independently H or alkyl, or together are —(CH2)q—,
- p is 0, 1, 2, 3 or 4, and
- q is 4 or 5.
Dependencies are inferred from the claim text.