Orally administered peptides to ameliorate atherosclerosis
AssigneeThe Regents of the University of California
InventorsAlan M. Fogelman, Gattadahalli M. Anantharamaiah, Mohamad Navab
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Abstract
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route.
Claims61
A peptide that ameliorates a symptom of atherosclerosis, wherein:
- said peptide comprises the amino acid sequence of SEQ ID NO:5;
- and
- said peptide comprises at least one “D” amino acid residue.
A composition suitable for administration to a mammal, that ameliorates a symptom of atherosclerosis, wherein said composition comprises:
- a pharmaceutically acceptable excipient;
- and
- a peptide comprising the amino acid sequence of SEQ ID NO:5, wherein said peptide comprises at least one “D” amino acid residue, and wherein said peptide has a first protecting group attached to an amino terminal and a second protecting group attached to a carboxyl terminal.
A method of ameliorating a symptom of atherosclerosis, said method comprising orally administering to an organism a peptide that:
- comprises the amino acid sequence of SEQ ID NO:5;
- and
- that comprises at least one “D” amino acid residue.
A method of ameliorating a symptom of atherosclerosis, said method comprising administering to an organism a peptide that
- comprises the amino acid sequence of SEQ ID NO:5;
- and
- that comprises at least one “D” amino acid residue.
A method of ameliorating a symptom of atherosclerosis, said method comprising orally administering to an organism a composition that comprises a peptide that:
- comprises the amino acid sequence of SEQ ID NO:5;
- that comprises at least one “D” amino acid residue;
- and
- wherein said peptide has a first protecting group attached to an amino terminal and a second protecting group attached to a carboxyl terminal.
A kit for ameliorating a symptom of atherosclerosis, said kit comprising a container containing a peptide that
- comprises the amino acid sequence of SEQ ID NO:5;
- and
- that comprises at least one “D” amino acid residue.
The kit of claim a 55, wherein said peptide is combined with a pharmaceutically acceptable excipient in a unit dosage formulation.
A kit for ameliorating a symptom of atherosclerosis, said kit comprising a container containing a composition suitable for oral administration that ameliorates a symptom of atherosclerosis, wherein said composition comprises a peptide that
- comprises the amino acid sequence of SEQ ID NO:5;
- that peptide comprises at least one “D” amino acid residue;
- and
- said peptide has a first protecting group attached to an amino terminal and a second protecting group attached to a carboxyl terminal.
Dependencies are inferred from the claim text.