US 6,664,229 B2 · Methods for treatment using novel ligands of the neuropeptide receptor HFGAN72

Abstract

Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose or treat diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

Claims2

Dependent claims

A method of increasing arousal in a sleep disorder selected from the group consisting of:

fatigue, narcolepsy, and jet-lag syndrome in a human, said method comprising the step of administering to a human in need thereof from about 10 μg/kg to about 1 mg/kg body weight, daily, of Lig 72a (SEQ ID NO:
3), in combination with a carrier.

Dependencies are inferred from the claim text.

Facts

Application

09/211,823Filed 15 Dec 1998 · us provisional application

Priority

15 Dec 1997

Published

US 2003/0087801 A18 May 2003

Granted

16 Dec 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification37 codes

C07K 16/28
Against material from animals or humans: against receptors, cell surface antigens or cell surface determinants
A61K 38/22
From animals; from humans: hormones
A61P 3/00
Drugs for disorders of the metabolism
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents

Methods for treatment using novel ligands of the neuropeptide receptor HFGAN72

Life of this patent

Methods for treatment using novel ligands of the neuropeptide receptor HFGAN72

Life of this patent

Abstract

Claims2