Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
AssigneesGenetics Institute, Inc., The United States of America as represented by the Department of Health and Human Services
InventorsThomas A. Wynn, Monica G. Chiaramonte, Mary Collins, Debra Donaldson, Lori Fitz, Tamlyn Neben, Matthew J. Whitters, Clive Wood
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Abstract
Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
Claims32
A method of treating tissue fibrosis in a mammalian subject, said method comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a protein and a pharmaceutically acceptable carrier to a subject in which treatment of fibrosis is desired, wherein said protein binds IL-13 and comprises the amino acid sequence of SEQ ID NO:4 or the amino acid sequence of SEQ ID NO:4 from amino acids 26 to 341, thereby treating tissue fibrosis in said subject.
A method of inhibiting the formation of tissue fibrosis in a mammalian subject, said method comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a protein and a pharmacologically acceptable carrier to a subject in which inhibition of formation of tissue fibrosis is desired, wherein said protein binds IL-13 and comprises the amino acid sequence of SEQ ID NO:4 or the amino acid sequence of SEQ ID NO:4 from amino acids 26 to 341, thereby inhibiting the formation of tissue fibrosis in said subject.
A method of treating tissue fibrosis in a mammalian subject, said method comprising administering to a subject in which treatment of tissue fibrosis is desired a therapeutically effective amount of a composition comprising (a) an IL-13 antagonist polypeptide comprising the amino acid sequence of an IL-13 binding soluble form of SEQ ID NO:4 from approximately amino acids 26-341, and (b) a pharmaceutically acceptable carrier, thereby treating tissue fibrosis in said subject.
A method of inhibiting formation of tissue fibrosis in a mammalian subject, said method comprising administering to a subject in which inhibition of formation of tissue fibrosis is desired a therapeutically effective amount of a composition comprising (a) an IL-13 antagonist polypeptide comprising the amino acid sequence of an IL-13 binding soluble form of SEQ ID NO:4 from approximately amino acids 26-341, and (b) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.