CD45 disrupted nucleic acid
AssigneeOntario Cancer Institute, University Health Network
InventorsTak Wah Mak, Kenji Kishihara
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Abstract
A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.
Claims5
A DNA sequence comprising at least exons 6-8 of a mouse CD45 DNA construct into which a marker gene sequence has been substituted for at least exon 6 and intron 6.
A mouse CD45 DNA construct comprising the fragment between the Sac I site in intron 5 and the BamHI site in intron 8, wherein a neo gene sequence has been substituted for at least exon 6 and intron 6.
Dependencies are inferred from the claim text.