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US 6,664,105 B1Granted
Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
AssigneesInsight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
InventorsIris Pecker, Israel Vlodavsky, Elena Feinstein
Life of this patent
Estimating the term…
Abstract
A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression are provided.
Claims5
An antisense oligonucleotide comprising a polynucleotide of a least 10 bases which specifically targets and inhibits the expression of the polynucleotide of SEQ ID No:
- 9 or SEQ ID NO:
- 13, wherein the polynucleotides SEQ ID NO:
- 9 and 13 encode polypeptides having heparanase catalytic activity.
A nucleic acid construct comprising SEQ ID NO:
- 13, encoding a polypeptide having heparanase catalytic activity.
Dependencies are inferred from the claim text.