Differentiation inhibitory agent
AssigneeAsahi Kasei Kabushiki Kaisha
InventorSeiji Sakano
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Abstract
Amino acids constituting a physiologically active molecule human delta 2; a gene arrangement thereof; and an antibody thereto. The human delta 2 molecule, at least the amino acid sequence described in SEQ ID NO: 1 of the sequence listing, functions as a chemical useful for proliferation of undifferentiated blood cells and inhibition of differentiation, and hence can be utilized as pharmaceuticals and medical supplies.
Claims11
A polypeptide comprising SEQ ID NO:
- 3.
A cell culture medium comprising:
- a) a polypeptide selected from the group consisting of SEQ ID NOS:
- 1, 2, and 3 and
- b) undifferentiated blood cell culture medium.
A method for culturing cells comprising cultivating cells in a cell culture medium, said cell culture medium comprising
- a) a polypeptide selected from the group consisting of SEQ ID NOS:
- 1, 2, and 3 and
- b) undifferentiated blood cell culture medium,
- wherein said cells are undifferentiated blood cells.
A method for suppressing differentiation of undifferentiated blood cells, comprising:
- culturing said cells with a polypeptide selected from the group consisting of SEQ ID No. 1, SEQ ID No. 2, and SEQ ID No. 3.
A method for suppressing growth of vascular endothelial cells, comprising:
- culturing said cells with a polypeptide selected from the group consisting of SEQ ID No. 1, SEQ ID No. 2, and SEQ ID No. 3.
Dependencies are inferred from the claim text.